+33 (0) 4 76 45 21 20 contact@smart-bioscience.com

Peptide synthesis services

(Arg)9 peptide – Cell-penetrating peptide

(Arg)9 is an cell-penetrating peptide made up of 9 arginine residues capable of traversing plasma membranes. It has been shown that Arg9 destabilize and disrupt the phospholipid bilayer allowing flow of ions across the membrane. (Arg)9 peptide plays an important role in efficient cellular uptake. The guanidinium group is a critical structural determinant for tight and rapid interactions with cell membrane. The cationic guanidinium group can form electrostatic interactions with anionic cell membranes components such as phospholipids and sulphated proteoglycans. This interaction can trigger the activation of specific intracellular signalling and cell internalization via various pathways. (Arg)9 peptide is used to deliver a variety of functionally active cargos such as peptides, small interfering RNA, oligonucleotides, plasmid DNA and liposomes into mammalian cells and plant cells with high translocation efficiency. (Arg)9 peptide can also be used to form chemical linkages with the cargo and act as a carrier peptide. It’s a Click (Arg)9.

Technical specification

AA sequence: RRRRRRRR
Disulfide bonds: 0
Length (aa): 9
Formula: C54H110N36O10
Molecular Weight: 1423.72 g/mol
CAS number: 143413-47-2
Source: Synthetic
Purity rate: > 95 %
Preparation and storage : Lyophilized powder, trifluoroacetate (TFA) salt format. Shipped at ambient temperature. Upon receipt, store lyophilized peptide at -20°C or lower. Reconstituted peptide can be aliquoted and stored at -20°C or lower. Avoid repeated freeze/thaw cycles.


PeptideProduct catalog 1Size 1Price 1 € HTProduct catalog 2Size 2Price 2 € HT
(Arg)9 peptideSB019-1MG1 mg80SB019-5*1MG5x1 mg280
FAM-(Arg)9SB020-1MG1 mg180SB020-5*1MG5x1 mg630
Alcyne-(Arg)9SB021-1MG1 mg200SB021-5*1MG5x1 mg700