T22 peptide – Potent CXCR4 antagonist
T22 peptide, also known as [Tyr5,12,Lys7]-polyphemusin II peptide, is a short, positively charged peptide, analog of polyphemusin peptide which exerts a strong anti- HIV activity. Polyphemusins are known to inhibit the growth of gram-negative bacteria and some fungi such as Candida Albicans. T22 peptide is a potent antagonist of CXCR4 (IC50 = 5.05 nM), a co-receptor used by HIV to penetrate cells.
It has been suggested that T22 peptide exerts its effect against HIV-1 especially by blocking virus-cell fusion and that T22 might interact with HIV envelope protein (such as gp120 ) and T-cell surface protein. T22 peptide antiviral activity has been shown on HIV-infected MT-4 cells with an IC50 of 0.008 µg/mL (2.6 nM). The cytotoxic concentration on HIV virus (CC50) of T22 peptide is 54 µg/mL (17 mM).
AA sequence: RRWCYRKCYKGYCYRKCR-NH₂
Disulfide bonds: Cys4-Cys17; Cys8-Cys13
Length (aa): 18
Molecular Weight: 2487 g/mol
CAS number: N/A
Purity rate: > 95%
Preparation and storage : Lyophilized powder, trifluoroacetate (TFA) salt format. Shipped at ambient temperature. Upon receipt, store lyophilized peptide at -20°C or lower. Reconstituted peptide can be aliquoted and stored at -20°C or lower. Avoid repeated freeze/thaw cycles.
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