mBD3 peptide – Potent antimicrobial peptide
Mouse Beta-Defensin 3 (mBD3) peptide, a homolog of human beta-defensin 2 (hBD2), is a cysteine-rich cationic antimicrobial peptide of 41 amino acids which belongs to the defensins family.
Defensin peptides are cationic peptides originally produced in various organs. They are involved in the protection against different kinds of pathogens like bacteria, fungi, and several viruses and play an important role in inflammation and wound repair.
mBD3 peptide showed antimicrobial activity against Gram-negative bacteria S.Aureus and S.pyogenes and against Gram-positive bacteria like certain strains of P.Aeruginosa (MIC of 8 µg/mL) and E.coli (MIC of 16 µg/mL). An antimicrobial activity has also been demonstrated against C.Albicans.
The in vivo and in vitro efficiency of mBD3 peptide against viruses like influenza was also shown. mBD3 peptide can be interesting for therapeutic applications.
AA sequence: KKINNPVSCL RKGGRCWNRC IGNTRQIGSC GVPFLKCCKR K
Disulfide bonds: Cys8-Cys37, Cys15-Cys30, Cys20-Cys38
Length (aa): 41
Molecular Weight: 4617.57 g/mol
CAS number: N/A
Purity rate: > 95%
Preparation and storage : Lyophilized powder, trifluoroacetate (TFA) salt format. Shipped at ambient temperature. Upon receipt, store lyophilized peptide at -20°C or lower. Reconstituted peptide can be aliquoted and stored at -20°C or lower. Avoid repeated freeze/thaw cycles.
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